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75+ Scientific Articles and Nutranize Zone Ingredients

75+ Scientific Articles and Nutranize Zone Ingredients

Based on scientific evidence

Every ingredient in Nutranize Zone supports prednisone nutrient repletion.*

Zone counterbalances the effects of prednisone in depleting nutrients or interfering with the metabolism of nutrients.*

Click on the Zone ingredient name below to find a list of studies showing nutrient depletion caused by prednisone. The nutrients that prednisone steals from your body include calcium, vitamin D, chromium, magnesium, potassium, folic acid, vitamins A & C, and melatonin, and are shown below with a star (*) next to the nutrient’s name.

Organized Alphabetically by Ingredient Name in Nutranize Zone

  1. Zhang Y, Li X, Zou D, et al. J Clin Endocrinol Metab 2008;93:2559-65. PMID: 18397984; DOI: 10.1210/jc.2007-2404.
  2. Dong H, Wang N, Zhao L, Lu F. Evid Based Complement Alternat Med. 2012;2012:591654. PMID: 23118793; PMCID: PMC3478874; DOI: 10.1155/2012/591654.
  3. Yin J, Xing H, and Ye J. Metabolism 2008;57(5):712-717. PMID: 18442638; PMCID: PMC2410097; DOI: 10.1016/j.metabol.2008.01.013.
  4. Zhang H, Wei J, Xue R, et al. Metabolism 2010;59(2):285-292. PMID: 19800084; DOI: 10.1016/j.metabol.2009.07.029.
  5. Chekalina SI, Umurzakova RZ, Saliev KK, et al. Gematologiia i Transfuziologiia 1994;39(5):33-35. PMID: 7896030.
  1. Buckley L, Guyatt G, Fink HA, et al. 2017 American College of Rheumatology Guideline. Arthritis Rheumatol. 2017;69(8):1521-1537. PMID: 28585373; DOI: 10.1002/art.40137.
  2. Homik J, Suarez-Almazor ME, Shea B, et al. Cochrane Database Syst Rev. 2000;(2):CD000952. PMID: 10796394; DOI: 10.1002/14651858.CD000952.
  3. Briot K, Roux C.  RMD Open. 2015 Apr 8;1(1):e000014. PMID: 26509049; PMCID: PMC4613168; DOI: 10.1136/rmdopen-2014-000014.
  4. Hoes JN, Bultink IE, Lems WF. Expert Opin Pharmacother. 2015 Mar;16(4):559-71. PMID: 25626121; DOI: 10.1517/14656566.2015.997709.
  5. Mohn ES, Kern HJ, Saltzman E, et al. Pharmaceutics. 2018;10(1)pii: E36. PMID: 29558445; PMCID: PMC5874849; DOI: 10.3390/pharmaceutics10010036.
  6. Cappuccio FP, Elliott P, Allender PS, et al. Am J Epidemiol. 1995;142(9):935-945. PMID: 7572974.
  7. Cappuccio FP, Siani A, Strazzullo P. J Hypertens 1989;7(12):941-946. PMID: 2697729.
  8. Margolis KL, Ray RM, Van Horn L, et al. Hypertension 2008;52:847-55. PMID: 18824662; PMCID: PMC2791957; DOI: 10.1161/HYPERTENSIONAHA.108.114991.
  9. Caan B, Neuhouser M, Aragaki A, et al. Arch Intern Med 2007;167:893-902. PMID: 17502530; DOI: 10.1001/archinte.167.9.893.
  1. Khan A, Safdar M, Ali Khan M, et al. Diabetes Care 2003;26:3215-8. PMID: 14633804.
  2. Crawford P. J Am Board Fam Med 2009;22:507-12. PMID: 19734396; DOI: 10.3122/jabfm.2009.05.080093.
  3. Blevins SM, Leyva MJ, Brown J, et al. Diabetes Care 2007;30:2236-7. PMID: 17563345; DOI:10.2337/dc07-0098.
  4. Akilen R, Tsiami A, Devendra D, et al. Diabet Med 2010;27(10):1159-1167. PMID: 20854384; DOI: 10.1111/j.1464-5491.2010.03079.x.
  1. Ravina A, Slezak L, Mirsky N, et al. Diabet Med 1999;16:164-7. PMID: 10229312.
  2. Ravina A, Slezak L, Mirsky N, et al. J Trace Elem Exper Med 1999;12(4):375-378. DOI: https://doi.org/10.1002/(SICI)1520-670X(1999)12:4<375::AID-JTRA11>3.0.CO;2-R.
  3. Paiva AN, Lima JG, Medeiros AC, et al. J Trace Elem Med Biol. 2015;32:66-72. PMID: 26302914; DOI: 10.1016/j.jtemb.2015.05.006.
  4. Suksomboon N, Poolsup N, Yuwanakorn A. J Clin Pharm Ther. 2014 Jun;39(3):292-306. PMID: 24635480; DOI: 10.1111/jcpt.12147.
  5. Press RI, Geller J, Evans GW. West J Med. 1990 Jan;152(1):41-5. PMID: 2408233; PMCID: PMC1002252.
  6. Tian H, Guo X, Wang X, et al. Cochrane Database Syst Rev. 2013 Nov 29;(11):CD010063. PMID: 24293292; DOI: 10.1002/14651858.CD010063.pub2.
  7. Sala M, Breithaupt L, Bulik CM, et al. J Diet Suppl. 2017 Mar 4;14(2):191-199. PMID: 27835050.
  8. Docherty JP, Sack DA, Roffman M, et al. J Psychiatr Pract. 2005 Sep;11(5):302-14. PMID: 16184071.
  1. Taylor MJ, Carney S, Geddes J, et al.  Cochrane Database Syst Rev 2003;(2):CD003390. PMID: 12804463; DOI: 10.1002/14651858.CD003390.
  2. McRae MP. J Chiropr Med. 2009 Mar;8(1):15-24. PMID: 19646382; PMCID:PMC2697578; DOI: 10.1016/j.jcm.2008.09.001.
  1. Dong JY, Xun P, He K, et al. Diabetes Care. 2011;34(9):2116-22. PMID: 21868780; PMCID: PMC3161260; DOI: 10.2337/dc11-0518.
  2. Swain R, Kaplan-Machlis B. South Med J 1999;92:1040-7. PMID: 10586828.
  3. Larsson SC, Wolk A. J Intern Med 2007;262:208-14. PMID: 17645588.
  4. Mooren FC, Krüger K, Völker K, et al. Diabetes Obes Metab 2011;13:281-4. PMID: 21205110; DOI: 10.1111/j.1463-1326.2010.01332.x.
  5. Lasserre B, Spoerri M, Moullet V, et al. Magnes Res 1994;7:145-53. PMID: 7999529.
  6. Aydin H, Deyneli O, Yavuz D, et al. Biol Trace Elem Res. 2010;133(2):136-43. PMID: 19488681; DOI: 10.1007/s12011-009-8416-8.
  1. Dokoohaki S, Ghareghani M, Ghanbari A, et al. Steroids. 2017;128:32-36. PMID: 29061489; DOI: 10.1016/j.steroids.2017.10.006
  2. Posadzki PP, Bajpai R, Kyaw BM, et al. BMC Med. 2018;16(1):18. PMID: 29397794; PMCID: PMC5798185; DOI: 10.1186/s12916-017-1000-8.
  3. Hansen MV, Halladin NL, Rosenberg J, et al. Cochrane Database Syst Rev. 2015(4):CD009861. PMID: 25856551; DOI: 10.1002/14651858.CD009861.pub2.
  4. Brusco LI, Fainstein I, Marquez M, et al. Biol Signals Recept 1999;8:126-31. PMID: 10085474; DOI: 10.1159/000014580.
  5. Dollins AB, Zhdanova IV, Wurtman RJ, et al. Proc Natl Acad Sci USA 1994;91:1824-8. PMID: 8127888; PMCID: PMC43256.
  6. Zhdanova IV, Wurtman RJ, Lynch HJ, et al. Clin Pharmacol Ther 1995;57:552-8. PMID: 7768078; DOI: 10.1016/0009-9236(95)90040-3.
  7. Brzezinski A. N Engl J Med 1997;336:186-95. PMID: 8988899; DOI: 10.1056/NEJM199701163360306.
  8. Lissoni P, Tancini G, Barni S, et al. Recenti Prog Med 1996;87:582-5. PMID: 9066251.
  9. Grossman E, Laudon M, Zisapel N. Vasc Health Risk Manag. 2011;7:577-84. PMID: 21966222; PMCID: PMC3180511; DOI: 10.2147/VHRM.S24603.
  1. Garg A, Grundy SM. JAMA 1990;264:723-6. PMID: 2374275.
  2. American Society of Health-System Pharmacists Therapeutic Position Statement. Am J Health Syst Pharm 1997;54:2815-9. PMID: 9428952.
  1. Aburto NJ, Hanson S, Gutierrez H, et al. BMJ. 2013;346:f1378. PMID: 23558164; PMCID: PMC4816263; DOI: 10.1136/bmj.f1378.
  2. Whelton PK, He J, Cutler JA, et al. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PMID: 9168293.
  3. van Bommel E, Cleophas T. Int J Clin Pharmacol Ther. 2012;50(7):478-82. PMID: 22541753; DOI: 10.5414/CP201724.
  4. Bazzano LA, Green T, Harrison TN, et al. Curr Hypertens Rep. 2013 Dec;15(6):694-702. PMID: 24091874; PMCID: PMC4366416; DOI: 10.1007/s11906-013-0390-z.
  5. Adebamowo SN, Spiegelman D, Willett WC, et al. Am J Clin Nutr. 2015;101(6):1269-77. PMID: 25948665; PMCID: PMC4441806; DOI: 10.3945/ajcn.114.100354.
  1. Sperduto RD, Hu TS, Milton RC, et al. Arch Ophthalmol. 1993;111:1246-53. PMID: 8363468.
  1. Cumming RG, Mitchell P, Smith W. Ophthalmology. 2000;10:450-6. PMID: 10711880.
  2. Alaei Shahmiri F, Soares MJ, Zhao Y, et al. Eur J Nutr. 2013 Oct;52(7):1821-4. PMID:  23715873; DOI: 10.1007/s00394-013-0534-6.
  3. Alaei-Shahmiri F, Soares MJ, Zhao Y, et al. Diabetes Metab Syndr. 2015 Apr 29. pii: S1871-4021(15)00042-9. PMID: 25982678; DOI: 10.1016/j.dsx.2015.04.014.
  1. Evans JR, Lawrenson JG. Cochrane Database Syst Rev. 2017;7:CD000254. PMID: 28756618; DOI: 10.1002/14651858.CD000254.pub4.
  1. Dakshinamurti S, Dakshinamurti K. Can J Physiol Pharmacol. 2015;93(12):1083-90. PMID: 26281007; DOI: 10.1139/cjpp-2015-0098.
  2. Aybak M, Sermet A, Ayyildiz MO, et al. Arzneimittelforschung. 1995;45(12):1271-1273. PMID: 26281007 DOI: 10.1139/cjpp-2015-0098.
  1. McRae, MP. J Chiropr Med 2008;7(2):48-58. PMID: 19674720; PMCID: PMC2682928; DOI: 10.1016/j.jcme.2008.01.002.
  2. Deved V, Poyah P, James MT, et al. Am J Kidney Dis. 2009 Dec;54(6):1089-97. PMID: 19783342; DOI: 10.1053/j.ajkd.2009.06.040.
  3. Alster TS, West TB. Dermatol Surg. 1998 Mar;24(3):331-4. PMID: 9537007.
  1. Buckley L, Guyatt G, Fink HA, et al. 2017 American College of Rheumatology Guideline. Arthritis Rheumatol. 2017;69(8):1521-1537. PMID: 28585373; DOI: 10.1002/art.40137.
  2. Homik J, Suarez-Almazor ME, Shea B, et al. Cochrane Database Syst Rev. 2000;(2):CD000952. PMID: 10796394; DOI: 10.1002/14651858.CD000952.
  3. Briot K, Roux C. RMD Open. 2015 Apr 8;1(1):e000014. PMID: 26509049; PMCID: PMC4613168; DOI: 10.1136/rmdopen-2014-000014.
  4. Hoes JN, Bultink IE, Lems WF. Expert Opin Pharmacother. 2015 Mar;16(4):559-71. PMID: 25626121; DOI: 10.1517/14656566.2015.997709.
  5. Mohn ES, Kern HJ, Saltzman E, et al. Pharmaceutics. 2018 Mar 20;10(1). pii: E36. PMID: 29558445; PMCID: PMC5874849; DOI: 10.3390/pharmaceutics10010036.
  6. Richy F, Ethgen O, Bruyere O, Reginster JY. Osteoporos Int. 2004;15(4):301-310. PMID: 14740153; DOI: 10.1007/s00198-003-1570-5.
  7. de Nijs RN, Jacobs JW, Algra A, Lems WF, Bijlsma JW. Osteoporos Int. 2004;15(8):589-602. PMID: 15138667; DOI: 10.1007/s00198-004-1614-5.
  8. Amin S, LaValley MP, Simms RW, Felson DT. J Bone Miner Res. 2002;17(8):1512-1526. PMID: 12162505; DOI: 10.1359/jbmr.2002.17.8.1512.
  9. Caan B, Neuhouser M, Aragaki A, et al. Arch Intern Med. 2007;167:893-902. PMID: 17502530; DOI: 10.1001/archinte.167.9.893.
  10. Schnatz PF, Jiang X, Aragaki AK, et al. Obstet Gynecol. 2017;129(1):121-129. PMID: 27926633; PMCID: PMC5177479; DOI: 10.1097/AOG.0000000000001774.
  11. Ford JA, MacLennan GS, Avenell A, et al; RECORD Trial Group. Am J Clin Nutr. 2014 Sep;100(3):746-55. PMID: 25057156; DOI: 10.3945/ajcn.113.082602.
  1. Petrilli MA, Kranz TM, Kleinhaus K, et al. Front Pharmacol. 2017 Jun 30;8:414. PMID: 28713269; PMCID: PMC5492454; DOI: 10.3389/fphar.2017.00414.
  2. Nowak G, Siwek M, Dudek D, et al. Pol J Pharmacol. 2003 Nov-Dec;55(6):1143-7. PMID: 14730113.
  3. Strause L, Saltman P, Smith KT, et al. J Nutr. 1994;124:1060-4. PMID: 8027856; DOI: 10.1093/jn/124.7.1060.
  4. Hyun TH, Barrett-Connor E, Milne DB. Am J Clin Nutr. 2004 Sep;80(3):715-21. PubMed PMID: 15321813; DOI: 10.1093/ajcn/80.3.715.
  5. Dreno B, Trossaert M, Boiteau HL, et al. Acta Derm Venereol. 1992;72:250-2. PMID: 1357876.
  6. Lazzerini M, Wanzira H. Cochrane Database Syst Rev. 2016 Dec 20;12:CD005436. PMID: 27996088; PMCID: PMC5450879; DOI: 10.1002/14651858.CD005436.pub5.

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