Am I Crazy? The Psychiatric Side Effects of Prednisone

“Prednisone made me crazy.” “I started going crazy.” “I thought I was going crazy. Or possessed.” “My family thinks I’m crazy.”

Different people. Same drug. Same word.

If any of those sentences sound familiar, I want you to hear this first: it is not you. It is the drug. And by the end of this post, you will know when the psychiatric side effects of prednisone start, what order they tend to come in, how long they last, and what the research actually says about when they stop. Including if you are already off prednisone and still not yourself.

I’m Dr. Megan, a board-certified clinical pharmacist, a third-generation pharmacist, and someone who took high-dose prednisone myself. Before I started my prescription, my doctor sat me down and told me the insomnia was coming and I was going to have to deal with it. Because I’m a pharmacist, he asked me which medication I wanted to take alongside it for the sleep problems he knew would come. It was as though I wrote my own prescription with his signature.

I got the best version of that conversation that exists. And I still had days where I felt like a stranger in my own body.

Here’s how rare my version of that conversation is. Researchers sat with eight patients on long-term steroids and asked them about their experience. Six of the eight had memory and thinking problems they had never mentioned to anyone. Only one of those eight had ever been warned by a doctor that this could happen. One. Out of eight.

So if nobody warned you, and you are sitting there wondering what is wrong with you, stay with me.

Watch now!

TL;DR: Quick Summary

Prednisone acts on the same brain receptors as your body’s own stress hormone, and psychiatric side effects are common, documented, and real. Research shows 60% of people on prednisone experience a mood or anxiety disorder at some point during treatment. The median onset is 11.5 days. Symptoms tend to appear in order: euphoria and insomnia first, then depression and mood swings, then memory problems later. Most people recover fully once the dose comes down. Confusion clears in days. Mood takes up to six weeks. Withdrawal-related symptoms resolve in two to eight weeks. For some people it takes longer, and the research accounts for that too. If this is still affecting you months or years later, you are not an exception. You are in the literature.

Before We Go Any Further: Three Things You Need to Know

One. I am not telling you to stop your prednisone. Stopping this drug suddenly can be fatal. That is adrenal crisis, and it is not me being dramatic. You never stop prednisone cold turkey unless you are under a doctor’s supervision.

Two. If you are taking something for your mood right now, I am not telling you to stop that either. Not one pill.

Three. Prednisone also saves lives. Some of you are watching because it gave you your lungs back, or your kidneys back, or your vision back. The benefits can outweigh the risks. I am not here to talk you out of your medicine. I am here to give you the information you deserved before you filled the prescription.

Free Resource: The Prednisone Survival Guide

Everything I know about getting through this drug is in one free guide. The Prednisone Survival Guide covers the 25+ things to watch out for and what to do about each one. It’s the first thing I would hand you if you walked up to my pharmacy counter today.

Get the free Prednisone Survival Guide at predguide.com →

This resource is for educational purposes only and does not substitute the advice of your physician or pharmacist.

Why Prednisone Goes After Your Mind

Prednisone does not just work on your joints or your lungs. It works on your brain, because your brain is full of the receptors this drug was built to hit.

Prednisone is a synthetic copy of the hormone your body makes when you’re under severe stress. Picture your body being told it is under that level of stress. Twenty-four hours a day. For weeks. That is not a metaphor. That is the pharmacology.

And the first thing it takes is sleep. Then the mind follows.

Any kind of steroid can do this. That is a detail that matters and almost nobody mentions. A pill, a cream, a nasal spray, an inhaler, or an IV can all cause psychiatric side effects. They all count. They all add up.

How Many People Does This Affect?

In 2018, prednisone was the 31st most commonly prescribed drug in the United States, behind thyroid medicines, blood pressure medicines, and a few antibiotics. There were 23.2 million prescriptions written that year alone. By 2024, approximately ten million Americans took prednisone, representing nearly eighteen million prescriptions, making it one of the thirty-five most prescribed drugs in the country.

You are not alone in this. And almost none of you were warned.

More than half of people who take prednisone report a mood condition or mood swings as a result of taking it. There is roughly a 60% chance you will experience a mood or anxiety disorder while on this drug. While you may feel isolated and frustrated, that feeling of isolation is itself part of what the drug does. You are in very large company.

Am I Going Crazy?

While you may feel like you are going insane because of what prednisone is doing to your mind, you are not going crazy. Many people who take prednisone feel frustrated with themselves, not only because of the mental effects of this drug but also because of the physical changes: weight gain, moon face, acne. Naturally, this leaves people feeling confused and like a stranger in their own body.

It is not you. It is the drug.

I have been asked many times to address the psychiatric side effects of this medication. What follows is everything the research says, and everything I wish someone had told me.

What It Actually Looks Like: A Patient’s Story

One patient shared her experience from the research, and I want you to read it carefully because some of you are about to recognize yourself.

Three days after starting a high dose of prednisone, she began experiencing depression, intense fatigue, malaise, weight gain, and swelling in her lower extremities. She felt impaired and had difficulty falling asleep. She experienced impulsivity severe enough to cause her to be inappropriate in professional settings. Her mind was flooded with racing thoughts. Her memory problems became so severe that she started pinning notes to her own clothes so she would not forget her responsibilities and appointments.

Her doctor had told her she might become a little hyperactive. Nobody told her about any of that.

During other prednisone treatment cycles, her depression became so bad she sought help from a psychiatrist. Even after stopping prednisone, she continued to report memory problems, loss of cognitive clarity, and vulnerability to overreactive distress.

Do any of these symptoms sound familiar to you?

Three Proofs It Is the Drug, Not You

When you try to describe this to your doctor or your family and are told it’s your illness, or your age, or that you look fine, here are three pieces of evidence to have in your pocket.

One. Same illness. Same doctor.

Researchers in the UK pulled the records of 261,272 people prescribed an oral steroid and built a matched group with the same age, same sex, same doctor, and crucially, the same underlying illness. The only difference between the two groups was the steroid.

The steroid group had:

Five times the rate of delirium and confusion
Four times the rate of mania
Nearly twice the rate of depression

They controlled for your disease. The difference was the drug.

Two. Healthy people with no illness at all.

Twelve healthy volunteers with nothing wrong with them were given eighty milligrams of prednisone or a placebo for five days. Nine of the twelve reported changes in their own behavior. Healthy people. Five days. No underlying condition to blame.

Three. You can see it on brain imaging.

Researchers using one of the largest health databases in the world found that steroid users had measurable differences in the white matter of their brains. The actual wiring. That showed up with oral steroids and also with inhaled steroids.

I made a whole video about that study and I will link it below. I am sharing it not to frighten you, but so that the next time someone says this is all in your head, you can tell them it is not in your head. It is in your brain. And there are pictures.

The Psychiatric Side Effects of Prednisone

Someone taking prednisone may experience one or more of the following:

Irritability and mood swings (the most commonly reported by patients)
Euphoria or hypomanic, wired energy
Anxiety
Depression and low mood
Insomnia
Mania or unpredictable, labile mood
Memory problems, including difficulty with concentration, declarative memory, working memory, abstraction, and analysis
Delirium, confusion, or disorientation
Psychosis (rare, but real and documented)

The research confirms that two of the most commonly experienced psychiatric side effects of prednisone are anxiety and depression. A 2024 meta-analysis that pooled forty-nine studies found:

Depression: 22% of prednisone users
Delirium or confusion: 16%
Mania: 11%
Anxiety: 8%

And the authors say their numbers are probably underestimates.

In 2020, rheumatology researchers formally studied the patient perspective because, in their own words, the impact of these drugs from the perspective of the patient rather than the clinician had gone relatively unexplored. So they went and asked. The single most common finding was irritability and mood swings, which came up in roughly three out of four of the studies they reviewed. More than anything else. They identified seventy-one separate outcomes that mattered to patients, including a whole category called effect on participation, which is the research term for what prednisone does to your work, your marriage, and your role in your family.

How Common Are Psychiatric Side Effects by Dose?

The dose matters, but with an important caveat.

Under 40mg per day: approximately 1.3% have a serious psychiatric reaction
40 to 80mg per day: approximately 4.6%
Over 80mg per day: approximately 18.4%

Those taking lower doses generally had fewer psychiatric effects such as depression and anxiety. At doses greater than 40mg, 4.6% of people suffered from extreme psychiatric effects. At doses above 80mg, 18.4% had severe psychiatric side effects.

But hear the fine print almost nobody says: the dose predicts how likely this is. The dose does not predict the onset, the severity, the type, or how long it lasts. If you are on ten milligrams and you feel destroyed, you are not exaggerating and you are not weak. A low dose lowers your odds. It does not promise you a gentler version if you are hit.

In one study of people on long-term low-dose prednisone, seven and a half milligrams a day for more than six months, 60% had a steroid-induced mood or anxiety disorder at some point.

Do Psychiatric Side Effects Vary by Gender?

Yes. Studies show that women are more likely to experience depression on prednisone, while men are more likely to experience mania or delirium.

What About Age?

50% of children who take prednisone experience a behavior change, ranging from hyperactivity to sleep problems to memory impairments
Ages 18 to 30 are most likely to experience panic disorder
Ages 18 to 50 have an elevated risk of suicidal ideation (more on that below)
Adults over 80 are most likely to experience delirium, confusion, and disorientation
The elderly are also more likely to suffer from memory issues
The cognitive effects on concentration, recall, abstraction, and analysis have been called “steroid dementia” when extreme

When Do Psychiatric Side Effects Start?

In a review of seventy reported cases, the median time to onset was eleven and a half days.

39% experienced a reaction within the first week
62% within two weeks
83% within six weeks

So if symptoms hit you fast and you thought it was too soon to be the medication, it was not too soon. That is the normal timeline. Another study showed that most people experienced side effects within one week.

There is also an order to what appears when:

Short-term: euphoria and that hypomanic, wired feeling tends to come first
Longer into treatment: depression and mood lability
Even later: memory loss is more likely to happen later in treatment than in the beginning

It is possible to have a psychiatric side effect after just one dose. The dose does not predict the onset, severity, type, or duration. There is no way to predict in advance whether someone will be affected.

Psychiatric side effects can happen:

At any point during prednisone treatment
Immediately upon starting
During tapering and withdrawal
After stopping completely

Side Effects During Withdrawal

One study looked at the incidence of side effects specifically during the withdrawal period, while tapering off, and found the following rates per 100 person-years of prednisone use:

Depression: 11.2
Delirium, confusion, or disorientation: 3.9
Mania: 0.4
Panic disorder: 0.4
Suicide attempt: 0.03

During withdrawal, long-acting steroids tend to be harder. Dexamethasone stays in your body far longer than prednisone does. Coming off a long-acting steroid nearly doubled the risk of depression and raised the risk of confusion approximately fivefold.

A Note on Suicide Risk

Because prednisone can cause significant depression, there is a small but elevated risk of suicidal thinking. The risk is seven times greater than in people who have not taken prednisone. In terms of absolute numbers, it affects approximately 0.03 out of every 100 person-years of prednisone use.

If you are experiencing suicidal thoughts, please do not wait. In the US, call or text 988. You can also go to your nearest emergency department. This is a known, documented side effect of the medication. It is not a character failing. Help is available right now.

A Note on Steroid Psychosis

Psychosis is one of the rarest side effects of prednisone. It is also one of the most serious and the least discussed. They used to call it steroid psychosis because of how severe the psychiatric effects of prednisone can become.

One Prednisone Warrior’s wife shared what happened to her late husband:

“My husband was on lithium for a couple of decades. He was prescribed prednisone and it gave him night terrors. We got the doctors to wean him off sooner than planned but he had some sort of psychotic break and shot himself. I’ve been with him for 30 years, saw him manic, saw him depressed and this was not that. I’m just searching for information. I don’t know why psychosis isn’t included in listed side effects and I want to help change that. I don’t want anyone to have to face this tragedy.”

This is not meant to frighten you. While this is a rare occurrence, it is important to speak honestly about all of the side effects of this medication. If you or someone you love is experiencing symptoms that feel like a break from reality while on prednisone, contact a medical provider immediately.

Who Is Most at Risk?

All patients should be considered at risk and monitored during treatment, during withdrawal, and for some time afterward, watching for signs of changes in mood, memory, and behavior.

The newest research identifies the following as risk factors for psychiatric side effects:

High doses
Long courses of treatment
A personal history of any psychiatric condition
Older age
Being female

These are not moral categories. They are clinical risk factors that help you and your doctor know what to watch for.

When Do Psychiatric Side Effects Stop?

Here is what most people want to know, and the research has real numbers.

Most people recover fully once the dose comes down or the drug stops. That is the literature’s own conclusion.

Confusion and delirium: usually clear within a few days
Psychosis: generally takes more than a week to return to baseline
Depression, mania, or mixed mood states: can take up to six weeks to resolve after stopping
Withdrawal-related symptoms including low mood, anxiety, and bone-deep fatigue: generally resolve over two to eight weeks

The dose is the lever. Symptoms tend to start improving when the dose starts moving down. One community member who had been on 40mg and not sleeping reported that at 15mg things got noticeably better, and she has been at 5 to 10mg for two years with no noticeable psychiatric side effects. Another said she started to improve as soon as her dose was lowered.

If It Has Not Stopped Yet

Some of you just did the math on six weeks and it does not match your life. You are off prednisone. Or you are way down. And you are still not yourself.

You are not the exception that means something has gone uniquely wrong with you. You are in the research.

That same patient who pinned notes to her clothes continued to report memory problems, loss of cognitive clarity, and vulnerability to overreactive distress even after stopping. In one review of cases, 7% had memory problems that persisted, enough that researchers reached for the phrase steroid-induced dementia. Seven percent is a small number until it is you.

The same literature that gives recovery timelines also says every patient should be monitored during treatment, during withdrawal, and for some time afterward. Not just while you are still swallowing the pills.

Some of you have been carrying this alone because nobody believed you.

“The worse is the family that thinks you are just crazy because you look normal.”

“My family thinks I’m crazy. They dismiss my struggles as wanting attention. I basically stay alone, no social interaction.”

“My family doesn’t believe, care or support my illness.”

Remember those eight patients from the beginning of this post. Only one had been warned. Five never told their doctor what was happening because they were afraid of being thought insane. That was documented in 1990. It took until 2020 for researchers to formally ask patients what this drug does to them, and to write down that mood swings and irritability were the thing patients raised more than anything else.

Thirty years. Then somebody finally asked.

Telling your doctor that prednisone is changing your mind is not a confession. It is a symptom report. It is the same as telling them your ankles are swollen.

How to Cope with Psychiatric Side Effects of Prednisone

Step 1: First Ask — Should I Be Taking Prednisone?

Now that you have heard all of this, you may be wondering whether it is worth it to take prednisone. If there is nothing better and you have tried all the alternatives, then yes, the benefits can outweigh the risks. With up to 150 total possible side effects, the reason you are taking prednisone had better be important enough to justify that risk.

The scientific literature states directly: glucocorticoids in any form, whether oral, topical, inhaled, or parenteral, have the potential to disrupt HPA axis function and should be prescribed only if there is no effective non-glucocorticoid treatment for the medical condition.

In plain English: any kind of steroid, whether a pill, a cream, a nasal spray, an inhaler, or an IV, can cause side effects. They should only be prescribed if there is no alternative that works. Ask your doctor if there is another way to manage your condition before or alongside taking prednisone.

Step 2: Stop or Decrease Prednisone (Only Under Doctor Supervision)

The first-line clinical guidance for severe psychiatric side effects from prednisone is to reduce the dose or stop the drug, as quickly as is safely possible.

Situation 1: Side effects are worse than the benefits.

If the psychiatric side effects are so severe and disabling that you cannot tolerate them, getting off prednisone is the priority. You never stop prednisone cold turkey without doctor supervision. Stopping without a proper taper can be fatal. But getting off it, slowly and safely, is the goal.

Situation 2: The benefits are still important and you can lower the dose.

If prednisone treatment is still necessary but the psychiatric effects are significant, ask about lowering your dose. If you are on 40mg, ask about 20mg. It is important to taper slowly and to be monitored by a physician throughout.

Situation 3: You cannot lower the dose yet.

If prednisone is still absolutely necessary at its current dose, the coping strategies below are for you.

Walk in with a written log and say this: “I am not asking you to change anything today. I want to know whether my dose could be contributing to what I am experiencing, and whether there is any room to come down.”

Stay in touch with your doctor and report the side effects if you cannot tolerate them. They cannot help you with something you never told them.

Step 3: Four Practical Things You Can Start This Week

Write down the dates.

Get a piece of paper and make two columns. On the left: every dose change, the day you started, went up, came down, and the numbers. On the right: the day each symptom started, and the day anything changed. One page. When those two columns sit next to each other, the pattern shows up. Sometimes you will see it yourself. Almost always your doctor will, because physicians are trained to read exactly that pattern and almost nobody has ever handed them one.

Protect your sleep like it is the treatment. Because it is.

Ask about taking your dose earlier in the day. Ask about something to support sleep. Make the room dark and keep it dark. Sleep is where your brain repairs. You cannot repair without it.

Get two witnesses.

You need yourself plus two people who know you well, all watching how you are doing. This is the one side effect where the thing you would normally use to check on yourself is the thing the drug affected. You cannot always be your own witness. Tell two people you trust what to watch for, and believe them when they tell you what they are seeing. If someone in your life has been dismissing you, share this post with them.

Ask about the dose.

Not to change it yourself. To have the conversation. If you need a prescription medication to get through this, take it. There is no shame in getting the help you need. Being on one medication because of another one is frustrating. It is not a failure. Give yourself grace.

Step 4: Non-Prescription Ways to Cope

While prescription medications are sometimes necessary, I always recommend starting with non-prescription methods first or alongside them:

Meditation
Breathing techniques
A consistent bedtime routine, including turning screens off before bed
Exercise appropriate to your current energy and condition
Brain-challenging activities to support memory and cognition
Eating green vegetables and whole foods

Step 5: Prescription Treatments for Specific Symptoms

Prescription medications designed to treat psychiatric symptoms are an important tool if you have reached the point where you need them. There is no shame in that. According to clinical guidance, the best prescription options for specific psychiatric side effects of prednisone are:

Mood lability and mood changes: talk therapy
Delirium: haloperidol, atypical antipsychotics
Anxiety: sertraline (Zoloft), alprazolam (Xanax)
Insomnia: melatonin, diphenhydramine (Benadryl), zolpidem (Ambien)
Depression: sertraline (Zoloft), lithium
Memory: memantine (Namenda), lamotrigine (Lamictal), propranolol
Mania: lithium, olanzapine (Zyprexa), phenytoin, valproic acid
Psychosis: atypical antipsychotics, lithium, electroconvulsive therapy (ECT)

These methods can be used alone or combined. Remember, there is no shame in getting the help that you need.

A note on pharmacogenomic testing:

Many of the medications above work better for certain genetic profiles. If you are cycling through psychiatric medications without finding the right fit, pharmacogenomic testing is a saliva test that shows which drugs are most likely to work for your specific genes. This can save months of trial and error. Ask your pharmacist or prescriber about it.

Vitamin Deficiency and Psychiatric Changes on Prednisone

Here is a piece of this that the psychiatric research does not always connect to the mood and mental health picture: prednisone depletes the very vitamins tied to brain function and mental health.

A scientific review on medication-induced psychiatric disorders states directly: vitamins play an important role in mental health. Various mental health conditions could develop due to vitamin deficiencies. Folate deficiency has been linked to depression. Vitamin B1 deficiency is associated with amnesia, anxiety, irritability, depression, and insomnia. Vitamin B12 deficiency is associated with mood disorders, psychosis, irritability, confusion, and dementia. Vitamin D deficiency has been associated with acute mood disorders, psychosis, and depression.

Prednisone depletes all of these. It also depletes magnesium, which supports the calming neurotransmitter pathways prednisone suppresses. It suppresses melatonin from the very first doses, which is the pharmacological explanation for why sleep goes first. It increases excretion of B vitamins through the kidneys, directly affecting mood regulation and neurological function.

Prednisone steals nutrients. When you feel that loss, it often shows up as a mental health symptom. This is not a coincidence. It is chemistry.

What I Did to Cope, and Why I Created Nutranize Zone

The struggles I faced while taking prednisone caused me to ask myself: what can I possibly do to help? What can I do to prevent this from happening? How can I deal with these side effects?

Those questions eventually led me to create Nutranize Zone, a dietary supplement with vitamins and nutrients designed specifically for people who take prednisone.

Nutranize Zone is not a treatment for depression, anxiety, or any psychiatric condition. It does not replace any medication your doctor has prescribed. What it is designed to do is replenish the nutritional foundation prednisone is actively taking from you, so your brain and body have what they need to function as well as possible during and after your treatment.

The bedtime dose was designed with the brain and mood connection specifically in mind:

Magnesium glycinate to support the calming neurotransmitter pathways prednisone suppresses
Melatonin to replace what prednisone blocks from the first doses, allowing your brain to enter the repair sleep it needs
Methylfolate, the active form of folate that crosses the blood-brain barrier and supports mood regulation directly
Methylcobalamin, the active form of B12, which supports neurological function and is linked to mood stability

The morning dose adds chromium picolinate for blood sugar stability, additional B vitamins for energy and nerve function, vitamin C, zinc, and calcium.

Nutranize Zone is formulated to help calm your mood, support restful sleep, and fight against the nutrient depletion driving so many of these symptoms.

Learn more about Nutranize Zone here →

Always consult your healthcare provider before adding any supplement to your regimen.

Conclusion

After reading this, you now know that prednisone causes real psychiatric side effects, how and when they happen, who is most at risk, and what you can do about them. You also know that the research says most people recover fully, and that for those who take longer, that too is documented and understood.

No matter how bad these side effects are, please know that there is hope. There is healing.

There is a light at the end of this tunnel.

One line from the research stays with me.

“Educating patients about possible side effects and the need to report them is essential.”

That is the foundation of what I do here as the Prednisone Pharmacist. Making sure you know the things I did not know when I started taking this drug.

You are not crazy. You are on a drug that does this to people. It is not your fault. It is not your character. And for most people, it is not permanent.

Do not hesitate to get the help that you need.

Frequently Asked Questions

Is it normal to feel like a different person on prednisone?

Yes, and it is documented. Research shows roughly 60% of people on prednisone experience a mood or anxiety disorder at some point. Irritability and mood swings are the most commonly reported psychiatric symptoms by patients. It is not your personality. It is the drug acting on brain receptors it was designed to hit.

How quickly can prednisone affect your mood?

Faster than most people expect. In a review of reported cases, the median onset was 11.5 days. 39% of people had a reaction within the first week. 62% within two weeks. It is possible to notice changes after just one or two doses.

Can a low dose of prednisone still cause psychiatric side effects?

Yes. While higher doses carry higher risk, one study of people on as little as seven and a half milligrams per day for more than six months found that 60% had a steroid-induced mood or anxiety disorder at some point. A lower dose reduces your odds but does not guarantee a milder experience if you are affected.

How long do psychiatric side effects from prednisone last?

Most resolve once the dose comes down. Confusion and delirium typically clear in days. Depression, mania, and mixed mood states can take up to six weeks to resolve after stopping. Withdrawal-related mood symptoms resolve over two to eight weeks. Most people recover fully. For some, particularly those on high doses for long periods, recovery can take longer.

Can prednisone cause memory problems?

Yes. Memory impairment, difficulty concentrating, and problems with recall and analysis are all documented psychiatric side effects. In one review of cases, 7% had memory problems that persisted after stopping, significant enough that researchers used the phrase steroid-induced dementia. If you are experiencing cognitive symptoms, report them to your doctor and ask for monitoring.

What should I tell my doctor about psychiatric side effects?

Be specific. Bring a written log with two columns: dose changes on the left, symptom onset and changes on the right. Tell your doctor exactly what you are experiencing, when it started, and how it is affecting your daily life. Ask directly whether your dose could be contributing and whether there is any room to come down.

What vitamins does prednisone deplete that affect mood?

Prednisone depletes folate, B vitamins including B1 and B12, vitamin D, magnesium, and melatonin, all of which are directly linked to mood, sleep, and neurological function. Folate deficiency is linked to depression. B1 and B12 deficiencies are associated with anxiety, irritability, mood disorders, and memory problems. Vitamin D deficiency is linked to depression and psychosis.

Is there anything I can take to support my mood while on prednisone?

Non-prescription approaches include meditation, breathing techniques, exercise, a consistent sleep routine, and nutritional support. Nutranize Zone was designed to replenish the specific nutrients prednisone depletes that are linked to mood and brain function, including methylfolate, methylcobalamin, magnesium glycinate, and melatonin. It does not treat or cure any psychiatric condition, but it may support your body’s nutritional foundation during treatment. Always discuss any supplement with your healthcare provider first.

If I’m still struggling after stopping prednisone, should I be worried?

Not that something is uniquely wrong with you, but yes, you deserve continued monitoring and support. The literature says patients should be monitored during treatment, during withdrawal, and for some time afterward. Seven percent of patients had persistent memory problems after stopping. If you are still significantly affected, ask your doctor specifically about a cortisol level check and a full evaluation of your symptoms. You are not the exception. You are in the research.

Disclaimer: This content is for educational purposes only and does not substitute the advice of your physician or pharmacist. If you are experiencing suicidal thoughts, call or text 988 or go to your nearest emergency department. Always consult your healthcare provider before making changes to your medications or adding supplements. Nutranize does not diagnose, treat, cure, or prevent any disease.

References:
Reckart MD, Eisendrath SJ. Exogenous corticosteroid effects on mood and cognition: case presentations. Int J Psychosom. 1990;37(1-4):57-61. PMID: 2246106.
Fardet L, Petersen I, Nazareth I. Suicidal Behavior and Severe Neuropsychiatric Disorders Following Glucocorticoid Therapy in Primary Care. American Journal of Psychiatry. 2012;169(5):491–497. doi:10.1176/appi.ajp.2011.11071009.
Wolkowitz OM, Reus VI, Weingartner H, et al. Cognitive and behavioral effects of corticosteroids. Psychiatry Research. 1990;33(3):279–289. doi:10.1016/0165-1781(90)90076-N.
van der Meulen M, Amaya JM, Dekkers OM, Meijer OC. Association between use of systemic and inhaled glucocorticoids and changes in brain volume and white matter microstructure: a cross-sectional study using data from the UK Biobank. BMJ Open. 2022;12(8):e062446. doi:10.1136/bmjopen-2022-062446.
Koning ACAM, van der Meulen M, Schaap D, Satoer DD, Vinkers CH, van Rossum EFC, van Furth WR, Pereira AM, Meijer OC, Dekkers OM. Neuropsychiatric Adverse Effects of Synthetic Glucocorticoids: A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab. 2024 May 17;109(6):e1442-e1451. doi: 10.1210/clinem/dgad701. PMID: 38038629; PMCID: PMC11099480.
Cheah, J. T. L., Robson, J. C., Black, R. J., Goodman, S. M., Lester, S., Mackie, S. L., & Hill, C. L. (2020). The patient’s perspective of the adverse effects of glucocorticoid use: A systematic review of quantitative and qualitative studies. From an OMERACT working group. Seminars in Arthritis and Rheumatism, 50(5), 996–1005. https://doi.org/10.1016/j.semarthrit.2020.06.019
Lewis DA, Smith RE. Steroid-induced psychiatric syndromes: A report of 14 cases and a review of the literature. Journal of Affective Disorders. 1983;5(4):319–332. doi:10.1016/0165-0327(83)90022-8
Bolanos SH, Khan DA, Hanczyc M, Bauer MS, Dhanani N, Brown ES. Assessment of mood states in patients receiving long-term corticosteroid therapy and in controls with patient-rated and clinician-rated scales. Ann Allergy Asthma Immunol. 2004 May;92(5):500-5. doi: 10.1016/S1081-1206(10)61756-5. PMID: 15191017
Gostoli S, Carrozzino D, Raimondi G, Subach R, Gigante G, Rafanelli C. Corticosteroid-induced manic and/or psychotic symptoms: a systematic review. Front Pharmacol. 2025 Jul 22;16:1628765. doi: 10.3389/fphar.2025.1628765. PMID: 40766761; PMCID: PMC12321511.
Warrington, T. P., & Bostwick, J. M. (2006). Psychiatric adverse effects of corticosteroids. Mayo Clinic Proceedings, 81(10), 1361–1367. https://doi.org/10.4065/81.10.1361
Judd LL, Schettler PJ, Brown ES, et al. Adverse Consequences of Glucocorticoid Medication: Psychological, Cognitive, Behavioral Effects. Am J Psychiatry. 2014;171(10):1045-51.
Raju NN, Kumar KSVRNP, Nihal G. Management of Medication-Induced Psychiatric Disorders. Indian J Psychiatry. 2022;64(Suppl 2):S281-S291. PMID: 35602361
Huynh G, Reinert JP. Pharmacological Management of Steroid-Induced Psychosis: A Review of Patient Cases. J Pharm Technol. 2021 Apr;37(2):120-126. doi: 10.1177/8755122520978534. Epub 2020 Dec 2. PMID: 34752563; PMCID: PMC7953074.