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Which Supplement Ingredients Counteract Prednisone Side Effects?

Which Supplement Ingredients Counteract Prednisone Side Effects?

When I was suffering from high-dose prednisone side effects plus receiving weekly chemotherapy treatments, I felt awful. The side effects were ruining my life. I was grateful that I wasn’t dying of my autoimmune condition, but it was hard to accept the price I was paying. Then one day, I had an epiphany. I knew right then that I needed to create a dietary supplement for people suffering from prednisone side effects.

I named it RxSideFx: my prescription for side effects.

It had never occurred to me until then that when prednisone caused nutrient depletion, the side effects were a direct result. I was thrilled to finally have discovered a way to counteract the prednisone side effects that I hated so much.

So I dived deep into the scientific literature to discover which nutrients prednisone depleted and how it related to the side effects. I put all of those nutrients into my dream list of supplement ingredients.

Then I went one step further:

I figured out which side effects prednisone caused that could be counteracted with vitamins, minerals, or herbs.

Many people have asked me my methods for doing so, and which ingredient helps with which side effect. And I’m finally pulling back the curtain to show you!

Watch my video where I explain which supplement ingredients had the most evidence to support their use by people on prednisone (you and me)!

Watch now!

P.S. It turns out I couldn’t use the name I dreamed of using, back when I had my epiphany for my RxSideFx business. The FDA doesn’t like it when the term “Rx” is used outside of prescription drugs, so that got shut down.

Instead, I changed it to Nutranize. This name comes from a combination of Nutrition and Neutralize. We “Neutralize prednisone side effects through Nutrition.”

Then the supplement designed for people on Prednisone I named Zone, because it takes you out of the predni”zone” “Twilight Zone” and back into the Zone of health.

You can find Nutranize Zone at Nutranize.com

Nutranize Zone

The Natural Medicines Database

The next task was to find natural products, supplement, herbs, vitamins, or minerals that could counteract the side effects of prednisone. Because the dietary supplement industry is not highly regulated like the prescription drug industry, it can be difficult to find good data about the effectiveness and safety of the ingredients of dietary supplements.

The well-respected Natural Medicines Database provided a “comparative effectiveness checker.” This tool allowed me to enter a specific side effect of prednisone, such as osteoporosis, and the database listed all types of natural remedies that have been used for that condition.

The tool ranks each remedy by the quality of the research showing efficacy, in a ranking of

  1. Effective
  2. Likely Effective
  3. Possibly Effective
  4. Insufficient Reliable Evidence to Rate
  5. Possibly Ineffective
  6. Likely Ineffective
  7. Ineffective

Only including natural products with a high rating of Effective, Likely Effective, or Possibly Effective for all prednisone side effects yielded a potential list of 329 natural remedies.

Non-dietary remedies such as yoga or acupuncture were then excluded. Remedies that work best as a topical, injectable, or in large quantities were excluded next.

I ranked each possible remedy remaining as Y for “yes” use; M for “maybe” use; R for needs more “research”; and N for “no,” do not use.

The remedies that received a Y ranking had a high rating of Effective or Likely Effective for at least one prednisone side effect. Those receiving an R for more research were looked up in the Natural Medicines Database and were then given a Y, M, or N rating.

The side effects most commonly experienced were given a higher priority as well. This filtering and ranking system yielded a list of likely effective remedies for common prednisone side effects.

Nutrient Depletion Tool

In addition, I searched the Natural Medicines Database using their Nutrient Depletion tool. Which showed certain vitamins and minerals that prednisone potentially affects. This showed that prednisone moderately depletes calcium, chromium, magnesium, vitamin D, and zinc.

  • Figure 1: Effective and Likely Effective therapies for prednisone side effects
  • Figure 2: Possibly Effective therapies alphabetized by therapy
  • Figure 3: Possibly Effective therapies alphabetized by use

Dr. Megan Milne, PharmD, BCACP

Dr. Megan Milne, PharmD, BCACP, is an award-winning clinical pharmacist board certified in the types of conditions people take prednisone for. Dr. Megan had to take prednisone herself for an autoimmune condition so understands what it feels like to suffer prednisone side effects and made it her mission to counteract them as the Prednisone Pharmacist.

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