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What’s the WORST Side Effect of Prednisone💊?

What’s the WORST Side Effect of Prednisone💊?

Based on your experience…

What’s the WORST side effect of prednisone?

In my latest video, I lay out some options of what I think they might be based on research and what people complain to me about.

Show notes in the video:

What is the worst Side Effect of Prednisone?


The most tweeted side effects of prednisone and most patients experienced this in the first few months. A lot of people find it so disabling. So, disorienting so lonely that it is the worst side effect for them.

Moon Face

People find to be the worst side effect not because it feels painful but because they can’t recognize their own reflection in the mirror!

Weight Gain

Weight gain is the worst because it is rapid and it is wicked and it is hard to lose if you’re on prednisone like anxiety that you can’t do the things you used to do.

Mental Changes

Prednisone Mood Swings is one of the common side effects caused by prednisone.


One of the irreversible side effects and gives  the worst outcome which is osteonecrosis. Bone death is the worst side effect when you have to have a joint replacement.

Heart Disease

Having  a heart disease can also lead to early cardiac death.

Dr. Megan Milne, PharmD, BCACP

Dr. Megan Milne, PharmD, BCACP, is an award-winning clinical pharmacist board certified in the types of conditions people take prednisone for. Dr. Megan had to take prednisone herself for an autoimmune condition so understands what it feels like to suffer prednisone side effects and made it her mission to counteract them as the Prednisone Pharmacist.

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