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Prednisone Withdrawal as Dangerous as the Treatment?

Prednisone Withdrawal as Dangerous as the Treatment?

Desperate Question: Is Prednisone Withdrawal Real?

You might be wondering whether prednisone withdrawal is real. If so, find out the symptoms of prednisone withdrawal backed up by scientific evidence in this article. You won’t have to feel like the desperate Prednisone Warrior in a support group who asked:

“Does anyone have any resources I can share with my family to show that prednisone withdrawal is real?”

She suffered miserably while withdrawing from prednisone. Yet her family dismissed her complaints. They thought it was all in her head.

It’s not all in your head.

Prednisone withdrawal is REAL.

Prednisone Withdrawal Symptoms

  • fatigue
  • loss of energy
  • hypoglycemia (low blood sugar)
  • hypotonia (reduced strength)
  • nausea
  • muscle or joint pain
  • sleep disturbances
  • weight changes

What does withdrawal feel like?

Withdrawal feels like you’ve been hit by a bus. Or like you have the flu. People have described it as being unable to get off the couch.

Scientific Article Support for Prednisone Withdrawal

I didn’t personally suffer from prednisone withdrawal much.  But I have read enough published scientific literature from credible sources to know that prednisone withdrawal is a legitimate and miserable consequence some people experience when the dose of prednisone is decreased.

It shows that there are real people suffering from steroid withdrawal: like prednisone.

As we all know, prednisone causes an incredible amount of terrible side effects. Prednisone is responsible for 10% of adverse drug events! As bad as that sounds, the withdrawal of the drug may be as dangerous as those side effects!

The title of this post came from a scientific article and many of the facts are supported by that article. Watch this video to learn more about the side effects from prednisone withdrawal.

Watch now!

Why Prednisone Withdrawal May be as Dangerous as the Treatment Itself

Two things that might happen:

What is Prednisone Withdrawal Syndrome?

Insomnia while on Prednisone

Withdrawal is when a drug is taken away. Prednisone withdrawal syndrome (PWS) can also be called Steroid Withdrawal Syndrome (SWS) and can occur when prednisone is withdrawn too quickly from possibly not tapering slow enough.

Medications that can cause withdrawal:

  • For example, people taking prescription opioid pain killers may have withdrawal when they go “cold turkey” from their pain meds.
  • People taking benzodiazepines like Xanax may have terrible withdrawals lasting years.
  • People on prednisone can have an incredibly terrible withdrawal syndrome as well.

How does Prednisone Withdrawal Happen?

Prednisone withdrawal happens because when you take it, your body becomes completely dependent on it to deal with stress. Prednisone mimics and even replaces cortisol, our stress hormone, leading to our bodies no longer making cortisol on our own anymore.

For a more scientific description, your adrenal organ sitting on top of your kidney is no longer receiving the pituitary’s message in the form of ACTH, adrenocorticotrophic hormone, to make cortisol.

The whole HPA axis is completely disrupted by prednisone. The HPA axis is a signal system from your brain (hypothalamus) to your pituitary gland, to your adrenal gland (on top of your kidney).

HPA axis

When you stop taking prednisone suddenly, you go into withdrawal because there is no cortisol or prednisone, the cortisol mimicker.

Prednisone is an adrenal replacement hormone. It is mimicking the hormone in our body that our adrenal gland normally makes and so it’s blocking them from being made because we’re taking prednisone.

So, prednisone taper or tapering is really important. Since this will be hard for our adrenal gland to catch up. We really need to go slowly with prednisone so that over time the adrenal gland will start making more of its own hormone and relying less on prednisone.

If we take it off too fast our body will suffer Adrenal insufficiency and that is life-threatening!

Don’t go Cold Turkey!

The reason to NEVER EVER go “cold turkey” or stop taking prednisone without slowly tapering is that you can go into adrenal crisis and even die. Adrenal crisis is when your body can’t deal with stress and so you go into shock with low blood pressure, low blood sugar, and you can suddenly die.

Always taper off prednisone. Check out this article for tips of how to do so.

According to that article, you can have adrenal insufficiency (by lab values) and not have any symptoms. Basically, unless you have a very stressful event happen to you, you may not know that you have adrenal insufficiency.

Prednisone Withdrawal Treatment

What To Do First If You Think You Have Prednisone Withdrawal Syndrome

According to this article, it is very important that if you are experiencing prednisone withdrawal symptoms and you are going down in dose to follow these steps:

  1. First, consult your doctor and get a check-up just in case that these symptoms are actually an infection.
  2. “The reinstitution of oral steroids.” That means you may need to start taking prednisone again.

Adrenal Insufficiency vs. Withdrawal

Sometimes these two terms, adrenal insufficiency, and withdrawal are thrown around as if they mean the same thing.

At first, they kind of do…withdrawal is causing adrenal insufficiency. But long-term, adrenal insufficiency can be permanent and must be treated.

Another confusion is adrenal insufficiency vs. adrenal fatigue. Adrenal insufficiency is severe enough to require replacement hormones. Adrenal fatigue is less severe and does not require steroids.

For more details about Steroid Withdrawal, check out this video:

Steroid Withdrawal is Real

This video describes how steroid withdrawal from prednisone is real, and not in your head. Apparently YouTube considers this topic to be too advanced (not sure why) that it labeled it “age-restricted.” It should be just fine for any audience, so don’t hesitate to watch it to find out the scientific support for steroid withdrawal syndrome.

How long does it last? Prednisone Withdrawal Symptoms Duration?

Adrenal insufficiency can last a few days, a few weeks, or even up to a year, or more! It’s very individual and unpredictable. I hope someday we can do research to find out how to predict this better.

Is prednisone withdrawal 2 weeks max?

Watch my video answer to Jessica about how long to expect prednisone withdrawal symptoms to last.

Can Prednisone make you feel weak and shaky?

Yes, this is a possible symptom of prednisone withdrawal. Watch the video above to find out other symptoms you might feel.

Who gets Adrenal Insufficiency?

Prednisone causes near-universal adrenal insufficiency. That means that nearly everyone on prednisone can have this issue when they decrease in dose. Usually it goes away and your adrenal glands eventually recover.

That doesn’t mean you get the diagnosis of AI. Only if you have AI for a long time do you receive a diagnosis and treatment.

What should I do if I think I have AI?

Talk to your doctor! This can be life-threatening. And it is difficult to diagnose, so don’t be afraid to advocate for yourself.

What can I do? Prednisone Withdrawal Remedies?

Because I was so concerned with how prednisone made me feel, I created a way to help people who are taking or have taken prednisone. It does not treat or cure AI, but helps you cope with taking prednisone.

I created Nutranize® Zone™  to reduce your suffering by replenishing your nutrients so that you can recover from prednisone. And so when you give back the nutrients that prednisone steals, you are putting this balance in your favor. And so that can help you decide whether the balance benefits greater than risks. You can find it at Nutranize.com.

Nutranize Zone for Prednisone

Dr. Megan Milne, PharmD, BCACP

Dr. Megan Milne, PharmD, BCACP, is an award-winning clinical pharmacist board certified in the types of conditions people take prednisone for. Dr. Megan had to take prednisone herself for an autoimmune condition so understands what it feels like to suffer prednisone side effects and made it her mission to counteract them as the Prednisone Pharmacist.

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