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75+ Scientific Articles and Nutranize Zone Ingredients

Avatar By Dr. Megan Milne, PharmD, BCACP
75+ Scientific Articles and Nutranize Zone Ingredients

Based on scientific evidence

Every ingredient in Nutranize® Zone supports prednisone nutrient repletion.*

Zone counterbalances the effects of prednisone in depleting nutrients or interfering with the metabolism of nutrients.* Prednisone causes nutrient depletion of 9+ nutrients. Dr. Megan created a dietary supplement especially for people on prednisone, Nutranize Zone for Prednisone, to give back the nutrients prednisone steals.

Find 75+ Scientific Articles Below

Click on the Zone ingredient name below to find a list of studies showing nutrient depletion caused by prednisone. The nutrients that prednisone steals from your body include calcium, vitamin D, chromium, magnesium, potassium, folic acid, melatonin, vitamins A, C, and K, and are shown below with a star (*) next to the nutrient’s name. Ingredients without a star are included to support the needs of people on prednisone.

Organized Alphabetically by Ingredient Name in Nutranize Zone:

  1. Wang YN, Liu X, He Y, et al. Blood. 2018;132(Supp 1):3769. DOI: https://doi.org/10.1182/blood-2018-99-113983
  2. Zhang Y, Li X, Zou D, et al. J Clin Endocrinol Metab. 2008;93:2559-65. PMID: 18397984; DOI: 10.1210/jc.2007-2404.
  3. Dong H, Wang N, Zhao L, Lu F. Evid Based Complement Alternat Med. 2012;2012:591654. PMID: 23118793; PMCID: PMC3478874; DOI: 10.1155/2012/591654.
  4. Yin J, Xing H, and Ye J. Metabolism 2008;57(5):712-717. PMID: 18442638; PMCID: PMC2410097; DOI: 10.1016/j.metabol.2008.01.013.
  5. Zhang H, Wei J, Xue R, et al. Metabolism 2010;59(2):285-292. PMID: 19800084; DOI: 10.1016/j.metabol.2009.07.029.
  6. Chekalina SI, Umurzakova RZ, Saliev KK, et al. Gematologiia i Transfuziologiia 1994;39(5):33-35. PMID: 7896030.
  7. Kong W et al. Nat Med. 2004;10(12):1344-51.
  8. Yang J et al. Evid Based Complement Alternat Med. 2012;2012:363845.
  9. Perez-Rubio K et al. Metab Syndr Relat Disord. 2013;11(5):366-9.
  10. Cao C et al. Exp Ther Med. 2019;17(4):3009-3014.
  11. Lee YS et al. Diabetes. 2006;55:2256-64.
  12. Brusq JM et al. J Lipid Res. 2006;47(6):1281-8.
  13. Jiang D et al. Lipids Health Dis. 2016;15:214.
  1. Buckley L, Guyatt G, Fink HA, et al. 2017 American College of Rheumatology Guideline. Arthritis Rheumatol. 2017;69(8):1521-1537. PMID: 28585373; DOI: 10.1002/art.40137.
  2. Homik J, Suarez-Almazor ME, Shea B, et al. Cochrane Database Syst Rev. 2000;(2):CD000952. PMID: 10796394; DOI: 10.1002/14651858.CD000952.
  3. Briot K, Roux C. Glucocorticoid-induced osteoporosis. RMD Open. 2015 Apr 8;1(1):e000014. PMID: 26509049; PMCID: PMC4613168; DOI: 10.1136/rmdopen-2014-000014.
  4. Hoes JN, Bultink IE, Lems WF. Expert Opin Pharmacother. 2015 Mar;16(4):559-71. PMID: 25626121; DOI: 10.1517/14656566.2015.997709.
  5. Mohn ES, Kern HJ, Saltzman E, et al. Pharmaceutics. 2018;10(1)pii: E36. PMID: 29558445; PMCID: PMC5874849; DOI: 10.3390/pharmaceutics10010036.
  6. Cappuccio FP, Elliott P, Allender PS, et al. Am J Epidemiol. 1995;142(9):935-945. PMID: 7572974.
  7. Cappuccio FP, Siani A, Strazzullo P. J Hypertens 1989;7(12):941-946. PMID: 2697729.
  8. Margolis KL, Ray RM, Van Horn L, et al. Hypertension 2008;52:847-55. PMID: 18824662; PMCID: PMC2791957; DOI: 10.1161/HYPERTENSIONAHA.108.114991.
  9. Caan B, Neuhouser M, Aragaki A, et al. Arch Intern Med 2007;167:893-902. PMID: 17502530; DOI: 10.1001/archinte.167.9.893.
  10. Buist RA. Drug-Nutrient Interactions–An Overview. Int Clin Nutr Rev. 1984;4(3):114-121.
  11. Van Staa TP, Leufkens HG, Cooper C. The Epidemiology of Corticosteroid-Induced Osteoporosis: A Meta-analysis. Osteoporos Int. 2002;13:777–787. doi: 10.1007/s001980200108. [PubMed]
  12. Hahn TJ, Halstead LR, Baran DT. Effects off short term glucocorticoid administration on intestinal calcium absorption and circulating vitamin D metabolite concentrations in man. J Clin Endocrinol Metab. 1981;52:111–115. doi: 10.1210/jcem-52-1-111. [PubMed]
  13. Buckley LM, Leib ES, Cartularo KS, et al. Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. A randomized, double-blind, placebo-controlled trial. Ann. Intern. Med. 1996;125:961–968. doi: 10.7326/0003-4819-125-12-199612150-00004. [PubMed]
  14. Van Staa TP, Leufkens HG, Cooper C. The Epidemiology of Corticosteroid-Induced Osteoporosis: A Meta-analysis. Osteoporos Int. 2002;13:777–787. doi: 10.1007/s001980200108. [PubMed]
  15. Hahn TJ, Halstead LR, Baran DT. Effects off short term glucocorticoid administration on intestinal calcium absorption and circulating vitamin D metabolite concentrations in man. J Clin Endocrinol Metab. 1981;52:111–115. doi: 10.1210/jcem-52-1-111. [PubMed]
  16. Buckley LM, Leib ES, Cartularo KS, et al. Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. A randomized, double-blind, placebo-controlled trial. Ann. Intern. Med. 1996;125:961–968. doi: 10.7326/0003-4819-125-12-199612150-00004. [PubMed]
  17. Adachi JD, Bensen WG, Bianchi F, et al. Vitamin D and calcium in the prevention of corticosteroid induced osteoporosis: A 3 year followup. J. Rheumatol. 1996;23:995–1000. [PubMed]
  18. Bijlsma JW, Raymakers JA, Mosch C, et al. Effect of oral calcium and vitamin D on glucocorticoid-induced osteopenia. Clin Exp Rheumatol. 1988;6:113–119. [PubMed] []
  19. Ringe JD, Cöster A, Meng T, et al. Treatment of glucocorticoid-induced osteoporosis with alfacalcidol/calcium versus vitamin D/calcium. Calcif Tissue Int. 1999;65:337–340. doi: 10.1007/s002239900708. [PubMed] [CrossRef] []
  1. Khan A, Safdar M, Ali Khan M, et al. Diabetes Care 2003;26:3215-8. PMID: 14633804.
  2. Crawford P. J Am Board Fam Med 2009;22:507-12. PMID: 19734396; DOI: 10.3122/jabfm.2009.05.080093.
  3. Blevins SM, Leyva MJ, Brown J, et al. Diabetes Care 2007;30:2236-7. PMID: 17563345; DOI:10.2337/dc07-0098.
  4. Akilen R, Tsiami A, Devendra D, et al. Diabet Med 2010;27(10):1159-1167. PMID: 20854384; DOI: 10.1111/j.1464-5491.2010.03079.x.
  1. Asbaghi O, Fatemeh N, Mahnaz RK, et al. Effects of chromium supplementation on glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2020 Nov;161:105098. doi: 10.1016/j.phrs.2020.105098. Epub 2020 Jul 28. PMID: 32730903.
  2. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med. 1999;16:164-7. PMID: 10229312.
  3. Ravina A, Slezak L, Mirsky N, et al. J Trace Elem Exper Med. 1999;12(4):375-378. DOI: https://doi.org/10.1002/(SICI)1520-670X(1999)12:4<375::AID-JTRA11>3.0.CO;2-R.
  4. Paiva AN, Lima JG, Medeiros AC, et al. J Trace Elem Med Biol. 2015;32:66-72. PMID: 26302914; DOI: 10.1016/j.jtemb.2015.05.006.
  5. Suksomboon N, Poolsup N, Yuwanakorn A. J Clin Pharm Ther. 2014 Jun;39(3):292-306. PMID: 24635480; DOI: 10.1111/jcpt.12147.
  6. Press RI, Geller J, Evans GW. West J Med. 1990 Jan;152(1):41-5. PMID: 2408233; PMCID: PMC1002252.
  7. Tian H, Guo X, Wang X, et al. Cochrane Database Syst Rev. 2013 Nov 29;(11):CD010063. PMID: 24293292; DOI: 10.1002/14651858.CD010063.pub2.
  8. Sala M, Breithaupt L, Bulik CM, et al. J Diet Suppl. 2017 Mar 4;14(2):191-199. PMID: 27835050.
  9. Docherty JP, Sack DA, Roffman M, et al. J Psychiatr Pract. 2005 Sep;11(5):302-14. PMID: 16184071.
  10. Mohn ES, Kern HJ, Saltzman E, et al. Pharmaceutics. 2018;10(1)pii: E36. PMID: 29558445; PMCID: PMC5874849; DOI: 10.3390/pharmaceutics10010036
  1. Henderson AM, Aleliunas RE, Loh SP, Khor GL, Harvey-Leeson S, Glier MB, Kitts DD, Green TJ, Devlin AM. l-5-Methyltetrahydrofolate Supplementation Increases Blood Folate Concentrations to a Greater Extent than Folic Acid Supplementation. J Nutr. 2018 Jun 1;148(6):885-890. doi: 10.1093/jn/nxy057. PMID: 29878267.
  2. Taylor MJ, Carney S, Geddes J, et al.  Cochrane Database Syst Rev 2003;(2):CD003390. PMID: 12804463; DOI: 10.1002/14651858.CD003390.
  3. McRae MP. J Chiropr Med. 2009 Mar;8(1):15-24. PMID: 19646382; PMCID:PMC2697578; DOI: 10.1016/j.jcm.2008.09.001.
  1. Cheung MM, Dall RD, Shewokis PA, et al. The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pressure: A randomized double-blinded controlled trial. Nutrition. 2022 Jul-Aug;99-100:111674. doi: 10.1016/j.nut.2022.111674. Epub 2022 Apr 1. PMID: 35576873.
  2. Dong JY, Xun P, He K, et al. Diabetes Care. 2011;34(9):2116-22. PMID: 21868780; PMCID: PMC3161260; DOI: 10.2337/dc11-0518.
  3. Swain R, Kaplan-Machlis B. South Med J 1999;92:1040-7. PMID: 10586828.
  4. Larsson SC, Wolk A. J Intern Med 2007;262:208-14. PMID: 17645588.
  5. Mooren FC, Krüger K, Völker K, et al. Diabetes Obes Metab 2011;13:281-4. PMID: 21205110; DOI: 10.1111/j.1463-1326.2010.01332.x.
  6. Lasserre B, Spoerri M, Moullet V, et al. Should magnesium therapy be considered for the treatment of coronary heart disease? II. Epidemiological evidence in outpatients with and without coronary heart disease. Magnes Res 1994;7:145-53. PMID: 7999529.
  7. Aydin H, Deyneli O, Yavuz D, et al. Short-Term Oral Magnesium Supplementation Suppresses Bone Turnover in Postmenopausal Osteoporotic Women. Biol Trace Elem Res. 2010;133(2):136-43. PMID: 19488681; DOI: 10.1007/s12011-009-8416-8.
  8. Rayssiguier Y. Role of magnesium and potassium in the pathogenesis of arteriosclerosis. Magnesium. 1984;3(4-6):226-38. PMID: 6399344.
  9. Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-70. doi: 10.1016/j.mehy.2006.01.047. Epub 2006 Mar 20. PMID: 16542786.
  10. Naggar VF, Khalil SA, Gouda MW. Effect of concomitant administration of magnesium trisilicate on GI absorption of dexamethasone in humans. J Pharm Sci 1978;67:1029-30.
  1. Dokoohaki S, Ghareghani M, Ghanbari A, et al. Steroids. 2017;128:32-36. PMID: 29061489; DOI: 10.1016/j.steroids.2017.10.006
  2. Posadzki PP, Bajpai R, Kyaw BM, et al. BMC Med. 2018;16(1):18. PMID: 29397794; PMCID: PMC5798185; DOI: 10.1186/s12916-017-1000-8.
  3. Hansen MV, Halladin NL, Rosenberg J, et al. Cochrane Database Syst Rev. 2015(4):CD009861. PMID: 25856551; DOI: 10.1002/14651858.CD009861.pub2.
  4. Brusco LI, Fainstein I, Marquez M, et al. Biol Signals Recept 1999;8:126-31. PMID: 10085474; DOI: 10.1159/000014580.
  5. Dollins AB, Zhdanova IV, Wurtman RJ, et al. Proc Natl Acad Sci USA 1994;91:1824-8. PMID: 8127888; PMCID: PMC43256.
  6. Zhdanova IV, Wurtman RJ, Lynch HJ, et al. Clin Pharmacol Ther 1995;57:552-8. PMID: 7768078; DOI: 10.1016/0009-9236(95)90040-3.
  7. Brzezinski A. N Engl J Med 1997;336:186-95. PMID: 8988899; DOI: 10.1056/NEJM199701163360306.
  8. Lissoni P, Tancini G, Barni S, et al. Recenti Prog Med 1996;87:582-5. PMID: 9066251.
  9. Grossman E, Laudon M, Zisapel N. Vasc Health Risk Manag. 2011;7:577-84. PMID: 21966222; PMCID: PMC3180511; DOI: 10.2147/VHRM.S24603.
  10. Demisch L, Demisch K, Nickelsen T. Influence of dexamethasone on nocturnal melatonin production in healthy adult subjects. J Pineal Res 1987;5:317-22.
  1. Garg A, Grundy SM. JAMA 1990;264:723-6. PMID: 2374275.
  2. American Society of Health-System Pharmacists Therapeutic Position Statement. Am J Health Syst Pharm 1997;54:2815-9. PMID: 9428952.
  1. Aburto NJ, Hanson S, Gutierrez H, et al. BMJ. 2013;346:f1378. PMID: 23558164; PMCID: PMC4816263; DOI: 10.1136/bmj.f1378.
  2. Whelton PK, He J, Cutler JA, et al. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PMID: 9168293.
  3. van Bommel E, Cleophas T. Int J Clin Pharmacol Ther. 2012;50(7):478-82. PMID: 22541753; DOI: 10.5414/CP201724.
  4. Bazzano LA, Green T, Harrison TN, et al. Curr Hypertens Rep. 2013 Dec;15(6):694-702. PMID: 24091874; PMCID: PMC4366416; DOI: 10.1007/s11906-013-0390-z.
  5. Adebamowo SN, Spiegelman D, Willett WC, et al. Am J Clin Nutr. 2015;101(6):1269-77. PMID: 25948665; PMCID: PMC4441806; DOI: 10.3945/ajcn.114.100354.
  6. Buist RA. Drug-Nutrient Interactions–An Overview. Int Clin Nutr Rev. 1984;4(3):114-121.
  7. Thelkeld DS, ed. Hormones, Adrenal Cortical Steroids, Glucocorticoids. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Apr 1991, 128b.
  1. Sperduto RD, Hu TS, Milton RC, et al. Arch Ophthalmol. 1993;111:1246-53. PMID: 8363468.
  1. Cumming RG, Mitchell P, Smith W. Ophthalmology. 2000;10:450-6. PMID: 10711880.
  2. Alaei Shahmiri F, Soares MJ, Zhao Y, et al. Eur J Nutr. 2013 Oct;52(7):1821-4. PMID:  23715873; DOI: 10.1007/s00394-013-0534-6.
  3. Alaei-Shahmiri F, Soares MJ, Zhao Y, et al. Diabetes Metab Syndr. 2015 Apr 29. pii: S1871-4021(15)00042-9. PMID: 25982678; DOI: 10.1016/j.dsx.2015.04.014.
  1. Evans JR, Lawrenson JG. Cochrane Database Syst Rev. 2017;7:CD000254. PMID: 28756618; DOI: 10.1002/14651858.CD000254.pub4.
  2. Hunt TK, Ehrlich HP, Garcia JA, et al. Effect of vitamin A on reversing the inhibitory effect of cortisone on healing of open wounds in animals and man. Ann Surg 1969;170:633-41.
  3. Shenai JP, Mellen BG, Chytil F. Vitamin A status and postnatal dexamethasone treatment in bronchopulmonary dysplasia. Pediatrics 2000;106:547-53.
  4. Georgieff MK, Radmer WJ, Sowell AL. The effect of glucocorticosteroids on serum, liver, and lung vitamin A and retinyl ester concentrations. J Pediatr Gastroenterol Nutr 1991;13:376-82.
  1. Dakshinamurti S, Dakshinamurti K. Can J Physiol Pharmacol. 2015;93(12):1083-90. PMID: 26281007; DOI: 10.1139/cjpp-2015-0098.
  2. Aybak M, Sermet A, Ayyildiz MO, et al. Arzneimittelforschung. 1995;45(12):1271-1273. PMID: 26281007 DOI: 10.1139/cjpp-2015-0098.
  3. Sur S, Camara M, Buchmeier A, et al. Double-blind trial of pyridoxine (vitamin B6) in the treatment of steroid-dependent asthma. Ann Allergy 1993;70:147-52.
  1. McRae, MP. Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials. J Chiropr Med 2008;7(2):48-58. PMID: 19674720; PMCID: PMC2682928; DOI: 10.1016/j.jcme.2008.01.002.
  2. Deved V, Poyah P, James MT, et al. Effect of topical vitamin C on postoperative carbon dioxide laser resurfacing erythema. Am J Kidney Dis. 2009 Dec;54(6):1089-97. PMID: 19783342; DOI: 10.1053/j.ajkd.2009.06.040.
  3. Alster TS, West TB. Dermatol Surg. 1998 Mar;24(3):331-4. PMID: 9537007.
  4. Buist RA. Drug-Nutrient Interactions–An Overview. Int Clin Nutr Rev. 1984;4(3):114-121.
  1. Buckley L, Guyatt G, Fink HA, et al. 2017 American College of Rheumatology Guideline. Arthritis Rheumatol. 2017;69(8):1521-1537. PMID: 28585373; DOI: 10.1002/art.40137.
  2. Skversky AL, Kumar J, Abramowitz MK, et al. Association of glucocorticoid use and low 25-hydroxyvitamin D levels: results from the National Health and Nutrition Examination Survey (NHANES): 2001-2006. J Clin Endocrinol Metab. 2011 Dec;96(12):3838-45. doi: 10.1210/jc.2011-1600. Epub 2011 Sep 28. PMID: 21956424.
  3. Homik J, Suarez-Almazor ME, Shea B, et al. Cochrane Database Syst Rev. 2000;(2):CD000952. PMID: 10796394; DOI: 10.1002/14651858.CD000952.
  4. Briot K, Roux C. RMD Open. 2015 Apr 8;1(1):e000014. PMID: 26509049; PMCID: PMC4613168; DOI: 10.1136/rmdopen-2014-000014.
  5. Hoes JN, Bultink IE, Lems WF. Expert Opin Pharmacother. 2015 Mar;16(4):559-71. PMID: 25626121; DOI: 10.1517/14656566.2015.997709.
  6. Mohn ES, Kern HJ, Saltzman E, et al. Pharmaceutics. 2018 Mar 20;10(1). pii: E36. PMID: 29558445; PMCID: PMC5874849; DOI: 10.3390/pharmaceutics10010036.
  7. Richy F, Ethgen O, Bruyere O, Reginster JY. Osteoporos Int. 2004;15(4):301-310. PMID: 14740153; DOI: 10.1007/s00198-003-1570-5.
  8. de Nijs RN, Jacobs JW, Algra A, Lems WF, Bijlsma JW. Osteoporos Int. 2004;15(8):589-602. PMID: 15138667; DOI: 10.1007/s00198-004-1614-5.
  9. Amin S, LaValley MP, Simms RW, Felson DT. J Bone Miner Res. 2002;17(8):1512-1526. PMID: 12162505; DOI: 10.1359/jbmr.2002.17.8.1512.
  10. Caan B, Neuhouser M, Aragaki A, et al. Arch Intern Med. 2007;167:893-902. PMID: 17502530; DOI: 10.1001/archinte.167.9.893.
  11. Schnatz PF, Jiang X, Aragaki AK, et al. Obstet Gynecol. 2017;129(1):121-129. PMID: 27926633; PMCID: PMC5177479; DOI: 10.1097/AOG.0000000000001774.
  12. Ford JA, MacLennan GS, Avenell A, et al; RECORD Trial Group. Am J Clin Nutr. 2014 Sep;100(3):746-55. PMID: 25057156; DOI: 10.3945/ajcn.113.082602.
  13. Van Staa TP, Leufkens HG, Cooper C. The Epidemiology of Corticosteroid-Induced Osteoporosis: A Meta-analysis. Osteoporos Int. 2002;13:777–787. doi: 10.1007/s001980200108. [PubMed]
  14. Hahn TJ, Halstead LR, Baran DT. Effects off short term glucocorticoid administration on intestinal calcium absorption and circulating vitamin D metabolite concentrations in man. J Clin Endocrinol Metab. 1981;52:111–115. doi: 10.1210/jcem-52-1-111. [PubMed]
  15. Buckley LM, Leib ES, Cartularo KS, et al. Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1996;125:961–968. doi: 10.7326/0003-4819-125-12-199612150-00004. [PubMed]
  16. Adachi JD, Bensen WG, Bianchi F, et al. Vitamin D and calcium in the prevention of corticosteroid induced osteoporosis: A 3 year followup. J. Rheumatol. 1996;23:995–1000. [PubMed]
  17. Bijlsma JW, Raymakers JA, Mosch C, et al. Effect of oral calcium and vitamin D on glucocorticoid-induced osteopenia. Clin Exp Rheumatol. 1988;6:113–119. [PubMed] []
  18. Ringe JD, Cöster A, Meng T, et al. Treatment of glucocorticoid-induced osteoporosis with alfacalcidol/calcium versus vitamin D/calcium. Calcif Tissue Int. 1999;65:337–340. doi: 10.1007/s002239900708. [PubMed] [CrossRef] []
  19. Trovato A, Nuhlicek DN, Midtling JE. Drug-nutrient interactions. Am Family Phys 1991;44:1651-8.
  20. Chesney RW, Mazess RB, Hamstra AJ, et al. Reduction of serum-1,25-dihydroxyvitamin-D, in children receiving glucocorticoids. Lancet 1978;ii:1123-5.
  21. Nielsen HK, Eriksen EF, Storm T, Mosekilde K. The effects of short-term, high-dose prednisone on the nuclear uptake of 1,25-dihydroxyvitamin D3 in monocytes from normal human subjects. Metabolism 1988;37:109-14.
  22. Avioli LV. Serum 25-hydroxyvitamin D concentrations in patients receiving chronic corticosteroid therapy. J Lab Clin Med 1977;23:399-404.
  1. Tanaka I, Oshima H. Vitamin K2 as a potential therapeutic agent for glucocorticoid-induced osteoporosis. Clin Calcium. 2007 Nov;17(11):1738-44. Japanese. PMID: 17982195.
  2. Shikano K, Kaneko K, Kawazoe M, et al. Efficacy of Vitamin K2 for Glucocorticoid-induced Osteoporosis in Patients with Systemic Autoimmune Diseases. Intern Med. 2016;55(15):1997-2003. doi: 10.2169/internalmedicine.55.6230. Epub 2016 Aug 1. PMID: 27477405.
  3. Zhang YL, Yin JH, Ding H, et al. Vitamin K2 Prevents Glucocorticoid-induced Osteonecrosis of the Femoral Head in Rats. Int J Biol Sci. 2016 Jan 28;12(4):347-58. doi: 10.7150/ijbs.13269. PMID: 27019620; PMCID: PMC4807155.
  4. Chen L, Shi X, Weng SJ, et al. Vitamin K2 Can Rescue the Dexamethasone-Induced Downregulation of Osteoblast Autophagy and Mitophagy Thereby Restoring Osteoblast Function In Vitro and In Vivo. Front Pharmacol. 2020 Aug 11;11:1209. doi: 10.3389/fphar.2020.01209. PMID: 32848799; PMCID: PMC7431688.
  1. Petrilli MA, Kranz TM, Kleinhaus K, et al. Front Pharmacol. 2017 Jun 30;8:414. PMID: 28713269; PMCID: PMC5492454; DOI: 10.3389/fphar.2017.00414.
  2. Nowak G, Siwek M, Dudek D, et al. Pol J Pharmacol. 2003 Nov-Dec;55(6):1143-7. PMID: 14730113.
  3. Strause L, Saltman P, Smith KT, et al. J Nutr. 1994;124:1060-4. PMID: 8027856; DOI: 10.1093/jn/124.7.1060.
  4. Hyun TH, Barrett-Connor E, Milne DB. Am J Clin Nutr. 2004 Sep;80(3):715-21. PubMed PMID: 15321813; DOI: 10.1093/ajcn/80.3.715.
  5. Dreno B, Trossaert M, Boiteau HL, et al. Acta Derm Venereol. 1992;72:250-2. PMID: 1357876.
  6. Lazzerini M, Wanzira H. Cochrane Database Syst Rev. 2016 Dec 20;12:CD005436. PMID: 27996088; PMCID: PMC5450879; DOI: 10.1002/14651858.CD005436.pub5.
  7. Buist RA. Drug-Nutrient Interactions–An Overview. Int Clin Nutr Rev. 1984;4(3):114-121.

An article by Emily Mohn called Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications showed that that for just calcium, vitamin D, potassium/sodium and chromium alone, there were at least 97 human studies documenting that this happens. Prednisone causes nutrient depletion of these five plus more nutrients and replenishment is necessary.

That’s why Dr. Megan invented Nutranize Zone for people on prednisone.

Is prednisone making you miserable, too?

Find replenishment

Dr. Megan created a supplement designed especially for people taking prednisone.*

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Dr. Megan Milne, PharmD, BCACP

Dr. Megan Milne, PharmD, BCACP, is an award-winning clinical pharmacist board certified in the types of conditions people take prednisone for. Dr. Megan had to take prednisone herself for an autoimmune condition so understands what it feels like to suffer prednisone side effects and made it her mission to counteract them as the Prednisone Pharmacist.

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